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Th pots that th concomitant us ZYLOPIM (allopuinol) and thi-azid diutics may contibut tth nhancmnt allopui-nol toxicity in som patints hav bn viwd in an attmpt tstablish a caus-and-ct lationship and a mchanism causation. viw ths cas pots indicats that th patints w mainly civing thiazid diutics hyptnsion and that tsts tul out dcasd nal unction sconday thyptnsiv nphopathy w not otn pomd. In thos patints in whom nal insuicincy was documntd, howv, th commndation tlow th dos ZYLOPIM (allopuinol) was not ollowd. Although a causal mchanism and a caus-and-ct lationship hav not bn stablishd, cunt vidnc suggsts that nal unction should b monitod in patints on thi-azid diutics and ZYLOPIM (allopuinol) vn in th absnc nal ailu, and dosag lvls should b vn mconsvativly adjustd in thos patints on such combind thapy i diminishd nal unction is dtctd.
Tll you doctand phamacist i you a allgic tallopuinol any oth mdications. tll you doctand phamacist what psciption and nonpsciption mdications, vitamins, nutitional supplmnts, and hbal poducts you a taking. B su tmntion any th ollowing: amoxicillin (Amoxil, Timox); ampicillin (Polycillin, Pincipn); anticoagulants (‘blood thinns’) such as waain (Coumadin); canc chmothapy dugs such as cyclophosphamid (Cytoxan) and mcaptopuin (Puinthol); chlopopamid (Diabins); diutics (‘wat pills’); mdications that suppss th immun systm such as azathiopin (Imuan) and cyclospoin (Noal, Sandimmun); oth mdications gout such as pobncid (Bnmid) and sulinpyazon (Antuan); and tolbutamid (Oinas). You doctmay nd tchang th doss you mdications monityou caully sid cts. tll you docti you hav hav v had kidny liv disas hat ailu. tll you docti you a pgnant, plan tbcom pgnant, a bast-ding. I you bcom pgnant whil taking allopuinol, call you docto. you should know that allopuinol may mak you dowsy. Dnot div a ca opat machiny until you know how this mdication acts you. ask you doctabout th sa us alcoholic bvags whil you a taking allopuinol. Alcohol may dcas th ctivnss allopuinol.
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aggressive hydration and allopurinol must be taken to prevent or alleviate severe electrolyte imbalances and renal toxicity during and following chemotherapy administration in patients with large, chemosensitive tumors.