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Mefloquine may cause psychiatric symptoms in a number of patientsranging from anxietyparanoiaand depression to hallucinations and psychotic behaviorOn occasionsthese symptoms have been reported to continue long after mefloquine has been stoppedRare cases of suicidal ideation and suicide have been reported though no relationship to drug administration has been confirmedTo minimize the chances of these adverse eventsmefloquine should not be taken for prophylaxis in patients with active depression or with a recent history of depressiongeneralized anxiety disorderpsychosisor schizophrenia or other major psychiatric disordersLariammefloquineshould be used with caution in patients with a previous history of depression.

Because of the long half-life of mefloquineadverse reactions to Lariammefloquinemay occur or persist up to several weeks after the last dose.

Mefloquine may cause psychiatric symptoms in a number of patientsranging from anxietyparanoiaand depression to hallucinations and psychotic behaviorOn occasionsthese symptoms have been reported to continue long after mefloquine has been stoppedRare cases of suicidal ideation and suicide have been reported though no relationship to drug administration has been confirmedTo minimize the chances of these adverse eventsmefloquine should not be taken for prophylaxis in patients with active depression or with a recent history of depressiongeneralized anxiety disorderpsychosisor schizophrenia or other major psychiatric disordersLariammefloquineshould be used with caution in patients with a previous history of depression.

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