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Methotrexate used to inhibit dihyrofolate reductase and select for dhfr overexpresssion.
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This medicine can pass into body fluidsurinefecesvomitCaregivers should wear rubber gloves while cleaning up a patient’s body fluidshandling contaminated trash or laundry or changing diapersWash hands before and after removing glovesWash soiled clothing and linens separately from other laundry.
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assessing renal function in patients who have received vancomycin may be prudent, so appropriate methotrexate dose modifications can be made.